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Preoperative radiation may enhance treatment response in patients with HR-positive, HER2-negative breast cancer

Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led to improved treatment responses prior to surgery, according to the results of the phase II P-RAD clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

Skipping sentinel lymph node biopsy may be safe for some early-stage breast cancer patients

Skipping sentinel lymph node biopsy (SLNB) in patients with clinically node-negative, hormonal receptor (HR)-positive, HER2-negative early-stage breast cancer did not compromise regional control or survival after a median five years of follow-up, according to results from the BOOG 2013-08 phase III clinical trial, presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

Frequency and quantity of alcohol consumption influence cancer risk

As Americans gear up for the holiday season, new research offers a timely reminder to reflect on the long-term health effects of raising a celebratory glass – or two.

11 Dec 2025

Researchers identify a distinct immuno-inflammatory biomarker across major psychiatric disorders

Individuals with psychiatric disorders exhibiting seemingly similar symptoms often respond very differently to the same treatment, suggesting that distinct biological processes are at work beneath the surface of similar clinical presentations.

11 Dec 2025

Study finds sharp rise in prescriptions for stimulant medications used to treat ADHD

A new Ontario-based study has found a significant rise in prescriptions for stimulant medications used to treat attention-deficit/hyperactivity disorder (ADHD), particularly among adults and females.

11 Dec 2025

Missing piece of myelin results in slower, less consistent signal transmission to the brain

Our nerve cells are surrounded by a protective layer (myelin). This protective layer allows signals to pass between cells incredibly quickly.

11 Dec 2025

Interventions to treat valvular heart disease in cancer patients significantly improve survival

Valvular heart disease, identified through cardiovascular imaging, is common in cancer patients. Interventions to treat valvular heart disease significantly improved survival.

11 Dec 2025

Shared genetic roots of 14 psychiatric disorders revealed

Researchers from the Psychiatric Genomics Consortium (PGC) report that most genetic influences on mental illness are shared across diagnostic categories, revealing a more interconnected biological landscape than traditional classifications suggest.

11 Dec 2025

Psoriasis caused by changes in the fat metabolism of skin cells

A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously unknown molecular mechanism that contributes to the development of psoriasis - and at the same time represents a potential biomarker for a new treatment concept.

11 Dec 2025

RSV can have profound, long-lasting effects in hospitalized adults

Respiratory syncytial virus, commonly known as RSV, is often associated with cold-like symptoms in young children.

11 Dec 2025

What happens to your body during an ultramarathon? New study reveals key metabolic changes

This study tracked ultramarathon runners across 100 km, 160.9 km, and 230 km events to examine real-world metabolic, hormonal, and muscle stress responses. Severe energy deficits, muscle damage, and heterogeneous hormonal shifts were observed, with the greatest strain seen in the 230 km distance.

10 Dec 2025

Driving simulator exposes early Parkinson’s impairments that routine tests fail to detect

A high-fidelity driving simulator detected subtle visuospatial, attentional, and reaction time impairments in people with mild to moderate Parkinson’s disease, even when standard cognitive tests appeared normal. The study shows that simulator-based assessments can uncover real-world driving difficulties linked to disease severity that traditional screening tools often miss.

10 Dec 2025

People with epilepsy and learning disabilities face preventable early deaths

A combination of missed prevention opportunities and health inequalities can result in the early deaths of people living with epilepsy and intellectual disabilities, a study has shown.

10 Dec 2025

How much omega-3 do you need daily? New global review reveals DHA and EPA requirements

Global and national guidelines for long-chain omega-3 intake vary widely across life stages, with many countries lacking clear recommendations. Most authorities advise at least 250 mg/day of EPA and DHA, yet population intakes remain far below optimal levels.

10 Dec 2025

Glucose-lowering drugs may reduce risk of developing epilepsy

A preliminary study of people with diabetes suggests that use of glucose-lowering GLP-1 drugs may be linked to a lower risk of developing epilepsy. The study was published on December 10, 2025, in Neurology, the medical journal of the American Academy of Neurology.

10 Dec 2025

Disrupted genome architecture drives lymphoma development

Cancer isn't just about broken genes-it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services.

10 Dec 2025

Mathematical modeling identifies strategies to eliminate cervical cancer

Cervical cancer is the fourth most common cancer for women in the world, with more than 660,000 new cases and nearly 350,000 deaths per year.

10 Dec 2025

Screen time and ADHD: why social media stands out from gaming and TV

Over four years in a large US cohort, greater social media use was associated with small but consistent increases in inattention symptoms in children, while video games and television were not. Genetic risk for ADHD did not modify this inattention association, and analyses supported a directional link from social media use to later attention difficulties.

10 Dec 2025

AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing terminal exhaustion and enhancing tumour control in mice. This metabolic reprogramming also boosts responsiveness to PD-1 blockade, suggesting a potential strategy to improve cancer immunotherapy.

10 Dec 2025

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Medical Research News

Preoperative radiation may enhance treatment response in patients with HR-positive, HER2-negative breast cancer

Skipping sentinel lymph node biopsy may be safe for some early-stage breast cancer patients

Frequency and quantity of alcohol consumption influence cancer risk

Researchers identify a distinct immuno-inflammatory biomarker across major psychiatric disorders

Study finds sharp rise in prescriptions for stimulant medications used to treat ADHD

Missing piece of myelin results in slower, less consistent signal transmission to the brain

Interventions to treat valvular heart disease in cancer patients significantly improve survival

Shared genetic roots of 14 psychiatric disorders revealed

Psoriasis caused by changes in the fat metabolism of skin cells

RSV can have profound, long-lasting effects in hospitalized adults

What happens to your body during an ultramarathon? New study reveals key metabolic changes

Driving simulator exposes early Parkinson’s impairments that routine tests fail to detect

People with epilepsy and learning disabilities face preventable early deaths

How much omega-3 do you need daily? New global review reveals DHA and EPA requirements

Glucose-lowering drugs may reduce risk of developing epilepsy

Disrupted genome architecture drives lymphoma development

Mathematical modeling identifies strategies to eliminate cervical cancer

Screen time and ADHD: why social media stands out from gaming and TV

AI turns routine pathology slides into powerful maps of the tumor immune landscape

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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