Metabolism News and Research

Latest Metabolism News and Research

Roche ships additional quantities of Tamiflu oral suspension

Roche announced today that it has begun shipping additional quantities of Tamiflu® (oseltamivir phosphate) oral suspension (liquid).

3 Dec 2009

New book presents latest research on neuroendocrine physiology

In this volume an international group of basic and clinical investigators presents their latest research on neuroendocrine physiology, advances in the control of the onset of puberty and its disorders, and basic and clinical aspects of the GH/IGF-1 and hypothalamic-pituitary-adrenal axes. An entire section is dedicated to pituitary tumors, including genetics and neuroimaging, and another covers the neuroendocrine control of substrate metabolism, including hypothalamic obesity and anorexia.

3 Dec 2009

Researchers to publish a paper on the availability of 'Spice' drugs online

A paper to be published this month by University of Hertfordshire researchers about the availability of 'Spice' drugs online will raise new concerns about its mood altering effects.

3 Dec 2009

Fruit flies use same molecular mechanisms as humans for maintaining cholestrol

More importantly, according to two new studies led by a University of Utah human geneticist, fruit flies use the same molecular mechanisms as humans to help maintain proper balances of cholesterol and a key form of stored fat that contributes to obesity. The findings mean that as researchers try to learn more about the genetic and biological processes through which people regulate cholesterol and fat metabolism, the humble fruit fly, also called Drosophila, can teach humans much about themselves.

2 Dec 2009

Over twenty new drug metabolism assays launched by Absorption Systems

Absorption Systems, a leader in drug safety and ADMET (absorption, distribution, metabolism, excretion and toxicity) testing, today announced the introduction of a more complete series of drug metabolism assays designed to support the pharmaceutical R&D process, from early-stage discovery through late-stage clinical development.

2 Dec 2009

World’s first 1000 MHz ultra-high field NMR AVANCE spectrometer installed at CRMN, France

Bruker BioSpin has successfully completed the installation of the world’s first 1000 MHz ultra-high field NMR AVANCE™ spectrometer at the Centre de Resonance Magnétique Nucléaire à Très Hauts Champs (CRMN) in Lyon, France (a joint research unit of CNRS, Ecole Normale Supérieure de Lyon and Université Lyon 1).

2 Dec 2009

FDA approves additional intended use of Roche's cobas TaqScreen MPX Test

Roche announced today that the United States Food & Drug Administration (FDA) approved an additional intended use for its licensed nucleic acid test, to screen source plasma in pools comprised of up to 96 individual donations. The test, called the cobas® TaqScreen MPX Test for use on the cobas s 201 system, is a qualitative, in-vitro test for the simultaneous, direct detection of the human immunodeficiency virus (HIV-1 Group M RNA, HIV-1 Group O RNA , HIV-2 RNA), hepatitis C virus RNA and hepatitis B virus DNA in human plasma.

From Roche Sequencing and Life Science 2 Dec 2009

New data demonstrating the strength of Novartis' hematology portfolio to be presented

Novartis announced today that new data, including a late-breaking presentation on Tasigna® (nilotinib) 200 mg capsules in a form of chronic myeloid leukemia, demonstrate the strength of the company's hematology portfolio in advancing the care of patients.

2 Dec 2009

J&JPRD submits an NDA for tapentadol ER tablets

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. announced today that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for tapentadol extended release (ER) tablets, an investigational oral analgesic for the management of moderate to severe chronic pain in patients 18 years of age or older.

2 Dec 2009

Research study on the function of orexin neurons in brain

Japanese research group led by Professor Yasuhiko Minokoshi and Dr. Tetsuya Shiuchi, scientists at the National Institute for Physiological Sciences, NIPS, Japan, found that meals stimulated with sweet taste and motivated with its anticipation regularly activates "orexin" in the brain and it stimulates muscle glucose metabolism via the sympathetic nervous system, thereby reducing blood glucose level in mice.

2 Dec 2009

Roche's MagNA Pure 96 System for nucleic acid purification evaluated

TriCore Reference Laboratories of Albuquerque, N.M., reported at a recent user meeting results of their research collaboration with Roche Applied Science in which they evaluated Roche´s new MagNA Pure 96 System for use in nucleic acid purification. The evaluation focused on the Roche system’s ability to process specimens for pathogen testing.

1 Dec 2009

Type 1 diabetes youth have abnormal insulin resistance that may increase risk of cardiovascular disease

According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), youth with type 1 diabetes have now been found to have abnormal insulin resistance. Having abnormal insulin resistance appears to negatively affect heart, blood vessel and exercise function in this population.

1 Dec 2009

Women with gestational glucose intolerance at risk of metabolic syndrome

Women who have gestational glucose intolerance (a condition less severe than gestational diabetes) exhibit multiple cardiovascular risk factors as early as three months after birth, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

1 Dec 2009

New research suggests high fat, energy-dense foods may activate genes that make us obese

Those extra helpings of gravy and dessert at the holiday table are even less of a help to your waistline than previously thought. According to a new research report recently appearing online in The FASEB Journal (http://www.fasebj.org), a diet that is high in fat and in sugar actually switches on genes that ultimately cause our bodies to store too much fat.

1 Dec 2009

Anti-Aging Institute of California offers 'Don't Pause' to get rid of menopause symptoms

Menopause - it's an unavoidable part of aging as a woman, and brings with it a host of uncomfortable symptoms that negatively impact quality of life. Hot flashes, poor sleep, mood swings, weight gain, night sweats and lethargy are just some of the life-altering symptoms of menopause and perimenopause.

30 Nov 2009

Scientists provide the first comprehensive picture of minimal cell

What are the bare essentials of life, the indispensable ingredients required to produce a cell that can survive on its own? Can we describe the molecular anatomy of a cell, and understand how an entire organism functions as a system? These are just some of the questions that scientists in a partnership between the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Centre de Regulacio Genòmica (CRG) in Barcelona, Spain, set out to address.

28 Nov 2009

Study on placebo effect

A short time ago, Swedish scientists published a paper suggesting the existence of a genetic disposition to respond to placebo, thus giving rise to debate in the media about a possible "placebo gene." In the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2009; 106[46]: 751-5), Matthias Breidert and Karl Hofbauer summarize the most recent data about placebos.

28 Nov 2009

Copper sequestering drug tetrathiomolybdate shown to be effective in treating Wilson disease

The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers.

27 Nov 2009

Scientists offer first genetic proof of new and rational treatment for osteoporosis

The so-called RANK protein and the molecule that binds to it, the RANK ligand or RANKL, form a focus of the work of Josef Penninger, director of the Institute of Molecular Biotechnology (IMBA) in Vienna. In 1999 his group deleted the RANKL gene from mice and showed that the RANK/RANKL system was the "master regulator" governing bone loss (Kong et al. 1999 Nature 402, 304-309).

26 Nov 2009

Roche's xCELLigence RTCA DP Instrument with CIM-Plate 16 enables real-time monitoring of cell migration

Cell migration is an important process in the development of organisms, as well as during immune surveillance and wound healing. For cancer development, the potential of cells to migrate or to grow invasively is, in addition to proliferation, the most important disease-causing factor. The inhibition of cell migration is a key target of the new anti-inflammatory therapies.

25 Nov 2009

Metabolism News and Research

Latest Metabolism News and Research

Roche ships additional quantities of Tamiflu oral suspension

New book presents latest research on neuroendocrine physiology

Researchers to publish a paper on the availability of 'Spice' drugs online

Fruit flies use same molecular mechanisms as humans for maintaining cholestrol

Over twenty new drug metabolism assays launched by Absorption Systems

World’s first 1000 MHz ultra-high field NMR AVANCE spectrometer installed at CRMN, France

FDA approves additional intended use of Roche's cobas TaqScreen MPX Test

New data demonstrating the strength of Novartis' hematology portfolio to be presented

J&JPRD submits an NDA for tapentadol ER tablets

Research study on the function of orexin neurons in brain

Roche's MagNA Pure 96 System for nucleic acid purification evaluated

Type 1 diabetes youth have abnormal insulin resistance that may increase risk of cardiovascular disease

Women with gestational glucose intolerance at risk of metabolic syndrome

New research suggests high fat, energy-dense foods may activate genes that make us obese

Anti-Aging Institute of California offers 'Don't Pause' to get rid of menopause symptoms

Scientists provide the first comprehensive picture of minimal cell

Study on placebo effect

Copper sequestering drug tetrathiomolybdate shown to be effective in treating Wilson disease

Scientists offer first genetic proof of new and rational treatment for osteoporosis

Roche's xCELLigence RTCA DP Instrument with CIM-Plate 16 enables real-time monitoring of cell migration

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production