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ThromboGenics and BioInvent report positive results for anti-PlGF cancer therapeutic TB-403

ThromboGenics NV and co-development partner BioInvent International AB today reported that the results from the first Phase l study of novel anti-cancer agent TB-403 showed that it is safe and well tolerated, with pharmacokinetic properties enabling it to be developed for the treatment of cancer

3 Jun 2008

Paclitaxel Poliglumex/Capecitabine regimen well tolerated and active in metastatic breast cancer

At the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO), data were presented from a phase II investigator-sponsored trial paclitaxel poliglumex (Opaxio, CT-2103) in combination with capecitabine in first-line treatment of patients with metastatic breast cancer (MBC).

3 Jun 2008

Aggression between nursing-home residents more common than widely believed

When people hear about elder abuse in nursing homes, they usually think of staff members victimizing residents. However, research by Cornell University faculty members suggests that a more prevalent and serious problem may be aggression and violence that occurs between residents themselves.

2 Jun 2008

Preventable adverse events in hospitals occur 3 times more among patients with deafness, blindness or psychiatric disorders

Preventable adverse events in hospitals occur 3 times more often among patients with communication problems, such as deafness, blindness, psychiatric disorders and multiple health issues or comorbidities, found researchers in this study of nearly 2,400 patient records from 20 hospitals in Quebec.

2 Jun 2008

Cetuximab and chemotherapy combination proves safe, effective for head and neck cancer patients

Patients treated for locally advanced head and neck cancer may respond better to treatment with the addition of cetuximab to chemotherapy, according to a University of Pittsburgh Cancer Institute (UPCI) phase II study. The results will be presented at the 44th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago as an oral presentation.

2 Jun 2008

Less than 1 in 5 patients receive treatment to prevent venous thrombosis after surgery

Fewer than 1 in 5 patients received post-discharge therapy to prevent life-threatening blood clots - venous thrombosis - after hip- or knee-replacement surgery, report Rahme and colleagues in a retrospective cohort study. Venous thrombosis is one of the leading causes of death among hospital patients. However, elderly patients have a 70% lower chance of dying within 3 months if they take an anticoagulant drug to prevent blood clots.

2 Jun 2008

Improving cancer diagnosis and support services for Asian patients

There is a need to remove the major ethnic inequalities which still exist in access to cancer services and outcomes, according to the latest edition of Science & Public Affairs.

2 Jun 2008

Many Gulf Coast residents affected by Hurricane Katrina continue to have mental health problems, study finds

More than half of Louisiana and Mississippi residents affected by Hurricane Katrina in August 2005 continue to experience significant mental health problems, according to a study released on Friday by the American Medical Association, the New Orleans Times-Picayune reports.

2 Jun 2008

Meniscal damage and joint malalignment predictors of cartilage loss

Marked by cartilage and bone degradation, progressive knee osteoarthritis (OA) is believed to result in part from a combination of several local mechanical factors. Lack of joint stability, poor joint alignment and injuries to the disks of meniscal tissue that cushion the knee all affect load distribution and the toll to the vulnerable OA knee.

2 Jun 2008

Study looks at the role of metformin as possible anti-tumor agent

Metformin, the common first-line drug for type 2 diabetes, may be effective in increasing pathologic complete response rates in diabetic women with early stage breast cancer who took the drug during chemotherapy prior to having surgery, paving the way for further research of the drug as a potential cancer therapy, according to researchers at The University of Texas M. D. Anderson Cancer Center.

2 Jun 2008

Celldex Therapeutics vaccine may double survival in patients with deadly brain tumors

A vaccine aimed at inducing immunity to the most common and deadly type of brain tumor may stave off recurrence and more than double survival in patients, according to a new study led by researchers in Duke's Preston Robert Tisch Brain Tumor Center.

2 Jun 2008

Functional Electrical Stimulation may benefit people with Parkinson's

The use of electrical impulses to stimulate weak or paralyzed muscles, called Functional Electrical Stimulation (FES), is often used to help stroke or multiple sclerosis patients to walk.

2 Jun 2008

Sugar-sweetened beverages may be contributing to increasing obesity rates

A recent study published in Pediatrics and led by researchers at Columbia University Mailman School of Public Health found that sugar-sweetened beverages (SSBs) are an increasingly large part of children and teens' diets.

2 Jun 2008

Bipolar disorder in adolescents is a huge risk factor for smoking and substance abuse

A study from the Massachusetts General Hospital (MGH) supports previous reports that adolescents with bipolar disorder are at increased risk for smoking and substance abuse.

2 Jun 2008

Gemcitabine with bevacizumab and radiotherapy safe for pancreatic cancer patients

Treating pancreatic cancer with a combination of chemotherapy, biotherapy and radiotherapy prior to surgery is safe and may be beneficial for patients, according to a University of Pittsburgh Cancer Institute (UPCI) study presented at the 44th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

2 Jun 2008

Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s

The prevalence of pre-cancerous masses in the colon is the same for average-risk patients who are 40 to 49 years of age and those who are 50 to 59 years of age, reports a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

2 Jun 2008

Short-term exposure to air pollution may increase risk of stroke or mini-stroke

Short-term exposure to low levels of particulate air pollution may increase the risk of stroke or mini-stroke, according to findings that suggest current exposure standards could be insufficient to protect the public.

2 Jun 2008

Anti-rejection drug sirolimus may prolong organ life in noncompliant kidney transplant patients

New research from the University of California, San Diego Department of Medicine, Division of Nephrology, shows that the anti-rejection drug sirolimus (brand name Rapamune) may help prolong the clinical benefit of transplanted kidneys and delay rejection, especially in patients who do not regularly take their prescribed medications (are "non-compliant"). While the transplant field has been highly successful at reducing rejection and graft loss in the first year, post-transplant, reducing risk for graft rejection in the long-term has proved more difficult.

2 Jun 2008

Are bunk bed safe?

Bunk bed-related injuries are not an issue of concern solely for parents of young children according to a study conducted by investigators at the Center for Injury Research and Policy of The Research Institute at Nationwide Children's Hospital.

2 Jun 2008

Study identifies most costly adverse events in children's hospitals

A large study of health records from 38 American children's hospitals has measured adverse events that most increase length of stay and overall cost. The researchers say their findings provide useful targets for hospital programs aimed at preventing harm to young patients.

2 Jun 2008

Drug Trial News

ThromboGenics and BioInvent report positive results for anti-PlGF cancer therapeutic TB-403

Paclitaxel Poliglumex/Capecitabine regimen well tolerated and active in metastatic breast cancer

Aggression between nursing-home residents more common than widely believed

Preventable adverse events in hospitals occur 3 times more among patients with deafness, blindness or psychiatric disorders

Cetuximab and chemotherapy combination proves safe, effective for head and neck cancer patients

Less than 1 in 5 patients receive treatment to prevent venous thrombosis after surgery

Improving cancer diagnosis and support services for Asian patients

Many Gulf Coast residents affected by Hurricane Katrina continue to have mental health problems, study finds

Meniscal damage and joint malalignment predictors of cartilage loss

Study looks at the role of metformin as possible anti-tumor agent

Celldex Therapeutics vaccine may double survival in patients with deadly brain tumors

Functional Electrical Stimulation may benefit people with Parkinson's

Sugar-sweetened beverages may be contributing to increasing obesity rates

Bipolar disorder in adolescents is a huge risk factor for smoking and substance abuse

Gemcitabine with bevacizumab and radiotherapy safe for pancreatic cancer patients

Prevalence of pre-cancerous masses in the colon same in patients in their 40s and 50s

Short-term exposure to air pollution may increase risk of stroke or mini-stroke

Anti-rejection drug sirolimus may prolong organ life in noncompliant kidney transplant patients

Are bunk bed safe?

Study identifies most costly adverse events in children's hospitals

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