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MedImmune advances clinical development of antibody targeting interleukin-9 in patients with asthma

MedImmune has announced that its clinical program studying an investigational treatment targeting interleukin-9 (IL-9) has advanced with the start of a new trial in patients with asthma.

19 Mar 2008

Lithium chloride slows development of inclusion body myositis

A new UC Irvine study finds that lithium chloride, a drug used to treat bipolar disorder, can slow the development of inclusion body myositis, a skeletal muscle disease that affects the elderly.

19 Mar 2008

Only two per cent of 700 paediatric drug trials included independent safety checks

Only two per cent of paediatric drug trials reported that they had established independent safety monitoring committees that can help lead to the early detection of adverse drug reactions, according to a major review in the April issue of Acta Paediatrica.

19 Mar 2008

Increased hepcidin expression: A novel oncogenic signalling mechanism

Historically anaemia, which is associated with colorectal cancer, has been attributed to blood loss.

19 Mar 2008

How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?

The Gram negative bacterium H pylori is involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma.

19 Mar 2008

HDL-associated protein gene linked to heart disease risk

The gene for the HDL-associated protein paraoxonase 1 (PON1) appears to be associated with coronary artery disease and with the risk of developing adverse cardiac events, and variations in both the PON1 gene and its related enzyme activity may increase the risk for cardiovascular disease events, according to a study in the March 19 issue of JAMA , a theme issue on Genetics and Genomics.

19 Mar 2008

$Variants of the gene LRP5 associated with increased risk of bone fractures, low bone mineral density$

Variants of the gene LRP5 associated with increased risk of bone fractures, low bone mineral density

Results from a large study indicate that variants of the gene LRP5 are associated with a significant increase in the risk of fractures, by up to 20 percent, and lower levels of bone mineral density in the spine and hip, according to a study in the March 19 issue of JAMA, a theme issue on Genetics and Genomics.

19 Mar 2008

Psychological stress resulting from the traumatic stress may damage this brain

Individuals who experience military combat obviously endure extreme stress, and this exposure leaves many diagnosed with the psychiatric condition of post-traumatic stress disorder, or PTSD.

19 Mar 2008

Do bacterial combinations result in enhanced cytokine production? No!

Probiotic bacteria, defined as living microorganisms that have beneficial effects on human health, have been used for the prevention and treatment of a diverse range of disorders.

19 Mar 2008

Treating chronic post-traumatic stress disorder with psychotherapy

A randomized controlled trial by Lyon investigators discloses the difficulties in treating chronic posttraumatic stress disorder with psychotherapy in the March issue of Psychotherapy and Psychosomatics.

19 Mar 2008

Sex, age, burn site associated with abnormal scarring after burn injury

Sex, age, burn site, number of surgical procedures and the type of skin graft are associated with abnormal scarring following burns, according to a report in the March/April 2008 issue of Archives of Facial Plastic Surgery, one of the JAMA/Archives journals.

18 Mar 2008

Uric acid may provide early clues to diabetic kidney disease

For patients with type 1 diabetes, increased levels of uric acid in the blood may be an early sign of diabetic kidney disease - appearing before any significant change in urine albumin level, the standard screening test, reports a study in the May 2008 issue of the Clinical Journal of the American Society of Nephrology.

18 Mar 2008

Long-term follow-up after percutaneous pulmonary radiofrequency ablation

Radiofrequency ablation (RFA) - an interventional treatment that "cooks" and kills lung cancer tumors with heat - greatly improves survival time from primary or metastatic inoperable lung tumors, according to a study released at the Society of Interventional Radiology's 33rd Annual Scientific Meeting.

18 Mar 2008

Trauma patients likely to experience moderately severe pain 1 year after injuries

Most patients have moderately severe pain resulting from their injuries one year after sustaining major trauma, according to a report in the March issue of Archives of Surgery, one of the JAMA/Archives journals.

18 Mar 2008

Study outlines risk of treatment-resistant infection following facelift surgery

About one-half percent of patients undergoing facelift surgery at one outpatient surgical center between 2001 and 2007 developed methicillin-resistant Staphylococcus aureus (MRSA) infections, according to a report in the March/April issue of Archives of Facial Plastic Surgery, one of the JAMA/Archives journals.

18 Mar 2008

Study examines changes in quality of life after head and neck cancer treatment

In the year following their first treatment, patients with head and neck cancer report declines in their physical quality of life but improvements in their mental health quality of life, according to a report in the March issue of Archives of Otolaryngology-Head & Neck Surgery.

18 Mar 2008