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Hypertension associated with risk for mild cognitive impairment

High blood pressure appears to be associated with an increased risk for mild cognitive impairment, a condition that involves difficulties with thinking and learning, according to a report in the December issue of Archives of Neurology.

10 Dec 2007

Being in good shape after 40 reduces risk of stroke

People who have good physical function after the age of 40 may lower their risk of stroke by as much as 50 percent compared to people who are not able to climb stairs, kneel, bend, or lift as well, according to research published in the December 11, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

10 Dec 2007

Mild chemo before stem cell transplant causes long-term remission of follicular lymphoma

Treating relapsed follicular lymphoma patients with a milder chemotherapy regimen before they receive a blood stem cell transplant from a donor resulted in long-term complete remission for 45 of 47 patients in a clinical trial, researchers at The University of Texas M. D. Anderson Cancer Center report at the 49th annual meeting of the American Society of Hematology.

10 Dec 2007

FDA approves trial for SKCC breast cancer vaccine

The Federal Drug Administration announced Friday approval of a Phase 1 clinical trial designed to study a breast cancer vaccine developed at the Sidney Kimmel Cancer Center.

10 Dec 2007

Anemia drugs linked with leukemic transformation in patients with primary myelofibrosis

Mayo Clinic researchers have reported the discovery of a link between erythropoiesis-stimulating agents (ESAs) and leukemic transformation (conversion to leukemia) of the blood disorder myelofibrosis.

10 Dec 2007

Doctors trained on patient simulators exhibit superior skills

Senior internal medicine residents who are trained in critical resuscitation skills on patient simulators become more skilled than residents who undergo traditional training, according to new research.

10 Dec 2007

Depression screening for cancer patients too often falls between the cracks

Depression is known to be associated with cancer yet too many cancer patients are not screened for this mental disorder, according to researchers from the Indiana University School of Medicine, the Regenstrief Institute and the Roudebush VA Medical Center.

10 Dec 2007

Umbilical cord blood transplant may confer advantages over bone marrow transplant for kids with life-threatening metabolic disorders

Children born with inherited metabolic disorders that cause organ failure and early death can be treated successfully with umbilical cord blood transplants from unrelated donors and, in some cases go on to live for many years, according to a study led by Duke University Medical Center researchers.

10 Dec 2007

Combination therapy including antibiotics may be beneficial for multiple sclerosis

A preliminary study suggests that combining a medication currently used to treat multiple sclerosis with an antibiotic may slow the progress of the disease, according to an article posted online today that will appear in the February 2008 print issue of Archives of Neurology.

10 Dec 2007

Children with sickle cell disease, silent strokes show some relief with blood transfusions

A group of children who have sickle cell disease and who experience silent strokes showed some relief from the silent strokes with blood transfusion therapy, researchers at Washington University School of Medicine in St. Louis have found.

10 Dec 2007

Belief, disbelief and uncertainty activate distinct regions of the brain

The capacity of the human mind to believe or disbelieve a statement is a powerful force for controlling both behavior and emotion, but the basis of these states in the brain is not yet understood.

10 Dec 2007

Abdominal obesity predicts heart disease

Abdominal obesity is a strong independent risk factor for heart disease, and using the waist-hip ratio rather than waist measurement alone is a better predictor of heart disease risk among men and women, researchers reported in a study published in Circulation: Journal of the American Heart Association.

10 Dec 2007

Study results from Zolinza (vorinostat) in combination with bortezomib for multiple myeloma trial

Results from two investigational Phase I trials of ZOLINZA (vorinostat) in combination with bortezomib provide preliminary anti-tumor activity in patients with relapsed and/or refractory multiple myeloma.

10 Dec 2007

Vaccine improves event-free survival for leukemia patients

Patients whose immune system responded to a peptide vaccine for leukemia enjoyed a median remission that was more than three times longer than non-responders, a team led by researchers at The University of Texas M. D. Anderson Cancer Center reports at the 49th Annual Meeting of the American Society of Hematology.

10 Dec 2007

Psychotherapy useful in treating PTSD in early stages

When treated within a month, survivors of a psychologically traumatic event improved significantly with psychotherapy, according to a new study presented at the American College of Neuropsychopharmacology (ACNP) annual meeting.

10 Dec 2007

New strategy for developing antidepressants

Researchers may be able to develop an antidepressant which takes effect almost immediately by directly targeting novel molecules in the brain instead of taking a less direct route, which can lead to longer times for medication to take effect, according to a new study presented at the American College of Neuropsychopharmacology (ACNP) annual meeting.

10 Dec 2007

Potential blood test to detect lung cancer

A test for four blood proteins may provide a less-invasive follow-up for patients who have suspicious lesions on chest radiographs or computerized tomography (CT) scans, according to a new study led by Duke University Medical Center researchers.

10 Dec 2007

Brain differences found in adolescents with mental illness

Puberty may have an impact on areas of the brain that contribute to bipolar disorder or schizophrenia in youth, according to a study presented at the annual meeting of the American College of Neuropsychopharmacology (ACNP).

10 Dec 2007

Stable sleep patterns and regular routines may improve outcomes in bipolar disorder

Bipolar disorder, commonly known as manic-depressive disorder, is highly influenced by the circadian system - the body's internal clock - and a specific kind of psychotherapy may help decrease irregularities in the circadian system that can trigger key symptoms of bipolar disorder, according to a study presented at the American College of Neuropsychopharmacology (ACNP) annual meeting.

10 Dec 2007

Possible genetic link between schizophrenia and cancer

A series of studies presented today at the American College of Neuropsychopharmacology (ACNP) annual meeting elucidates evidence that there is a genetic link between schizophrenia and cancer, providing a surprising possible scientific explanation for lower rates of cancer among patients with schizophrenia – despite having poor diets and high rates of smoking – and their parents.

10 Dec 2007

Drug Trial News

Hypertension associated with risk for mild cognitive impairment

Being in good shape after 40 reduces risk of stroke

Mild chemo before stem cell transplant causes long-term remission of follicular lymphoma

FDA approves trial for SKCC breast cancer vaccine

Anemia drugs linked with leukemic transformation in patients with primary myelofibrosis

Doctors trained on patient simulators exhibit superior skills

Depression screening for cancer patients too often falls between the cracks

Umbilical cord blood transplant may confer advantages over bone marrow transplant for kids with life-threatening metabolic disorders

Combination therapy including antibiotics may be beneficial for multiple sclerosis

Children with sickle cell disease, silent strokes show some relief with blood transfusions

Belief, disbelief and uncertainty activate distinct regions of the brain

Abdominal obesity predicts heart disease

Study results from Zolinza (vorinostat) in combination with bortezomib for multiple myeloma trial

Vaccine improves event-free survival for leukemia patients

Psychotherapy useful in treating PTSD in early stages

New strategy for developing antidepressants

Potential blood test to detect lung cancer

Brain differences found in adolescents with mental illness

Stable sleep patterns and regular routines may improve outcomes in bipolar disorder

Possible genetic link between schizophrenia and cancer

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