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New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

Researchers uncover new mutation mechanism driving cancer progression

Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a significant impact on young people and their families as treatment can require surgery or amputation.

15 Jan 2025

Study finds no increased glioma risk with hormone therapy use

It's not easy being a woman. Just look at the statistics. Women are more likely to have such debilitating conditions as osteoporosis, migraines, Alzheimer disease, depression, multiple sclerosis, and brain tumors. Sex hormones are often blamed. However, a new study suggests no link between hormone therapy (HT) and common brain tumors known as gliomas. Results of the study are published online today in Menopause, the journal of The Menopause Society.

15 Jan 2025

Study unravels the links between obesity and cancer

Obesity, recognized as a complex and growing health issue, is associated with an increased risk of various cancers. A comprehensive review provides insights into the mechanisms linking obesity to cancer risk and discusses potential clinical implications.

15 Jan 2025

Uncovering the neurobiological mechanisms of delta opioid receptor agonists

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use. This underscores the urgent need for novel, rapidly-acting therapeutic agents with minimal side effects.

15 Jan 2025

Dementia risk impacts family planning decisions

Living in a family where there is genetic risk for dementia significantly affects choices about having children and how to parent, finds a new study led by UCL researchers.

15 Jan 2025

Study uncovers mechanism for cognitive improvement in dementia

A University of the Basque Country (UPV/EHU) study proves that the WIN55.212-2 drug protects the brain and reverses the initial cognitive damage caused by dementia, and explains how it works

15 Jan 2025

New model analyzes CT scans to identify high-risk individuals

Researchers at Case Western Reserve University, University Hospitals and Houston Methodist will harness the power of artificial intelligence (AI) to more accurately predict risk of heart failure and other cardiovascular events, including estimating when an adverse event might occur, by developing an AI model that "learns" from patient scans.

15 Jan 2025

A new strategy for enhancing the production of protein-based drugs

An international team of researchers led by the University of California San Diego has developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.

15 Jan 2025

Exploring the psychological impact of "topical steroid withdrawal"

Painful skin and trouble sleeping are among the problems reported when tapering cortisone cream for atopic eczema. This has been shown by a study headed by the University of Gothenburg. Many users consider the problems to be caused by cortisone dependence.

15 Jan 2025

Proteomic mapping identifies biomarkers driving healthy aging and preventing chronic diseases

Scientists mapped the serum proteome longitudinally to uncover biomarkers linked to healthy aging and cardiometabolic diseases, revealing potential therapeutic targets.

14 Jan 2025

High-fat diet linked to impulsive behaviors and brain changes

Researchers examines how a high-fat diet modifies inhibitory control.

14 Jan 2025

Genetics, brain development, and mental health shape teen eating

Investigating the interplay of genetics, brain maturation, and mental health, this study reveals insights into adolescent eating behaviors and obesity risk.

14 Jan 2025

Gut microbiome dynamics reveal key factors influencing Enterobacteriaceae colonization

Analysis of gut microbiomes reveals co-colonization patterns and potential therapeutic targets against Enterobacteriaceae, addressing global health challenges.

14 Jan 2025

Time-restricted eating paired with exercise: Small changes, big impact

Study reveals that combining time-restricted eating with exercise results in small but significant reductions in fat mass and body fat percentage while preserving fat-free mass. However, variability in outcomes and short study durations highlight the need for further research.

13 Jan 2025

Retina vascular fingerprint offers non-invasive way to predict stroke risk

A vascular 'fingerprint' on the light sensitive tissue layer at the back of the eye-the retina-can predict a person's risk of stroke as accurately as traditional risk factors alone, but without the need for multiple invasive lab tests, finds research published online in the journal Heart.

13 Jan 2025

Australia sees a decline in type 2 diabetes, but disparities persist

Type 2 diabetes incidence in Australia decreased from 2010 to 2019 overall but rose among younger men and specific ethnic groups, highlighting persistent disparities.

13 Jan 2025

Researchers uncover role of perivascular cells in blood vessel dysfunction

Researchers at Oregon Health & Science University have uncovered how specialized cells surrounding small blood vessels, known as perivascular cells, contribute to blood vessel dysfunction in chronic diseases such as cancer, diabetes and fibrosis.

13 Jan 2025

COVID-19 infection linked to increased cases of ME/CFS

New findings from the National Institutes of Health's (NIH) Researching COVID to Enhance Recovery (RECOVER) Initiative suggest that infection with SARS-CoV-2, the virus that causes COVID-19, may be associated with an increase in the number of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) cases.

13 Jan 2025

New drug cocktail enhances CAR-T cells for cancer treatment

Preclinical research findings from the University of North Carolina Lineberger Comprehensive Cancer Center identified a cocktail of three different drugs that can be used to generate more robust immune system CAR-Ts (chimeric antigen receptor-T cells) to fight cancer.

13 Jan 2025