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Spatial aging clocks reveal how T cells and neural stem cells shape brain aging

Researchers developed spatial aging clocks to map brain cell aging, revealing how T cells accelerate aging and NSCs rejuvenate neighboring cells, offering new insights into brain health and interventions.

22 Dec 2024

Insulin degradation uncovered as a new driver of resistance

Researchers reveal insulin resistance may be driven by insulin degradation during transit in the bloodstream, challenging the belief that cell defects are the primary cause.

22 Dec 2024

Generating mutated proteins through adversarial attacks on the AlphaFold2 model

Announcing a new publication for Acta Materia Medica journal. Proteins are essential macromolecules that perform functions according to their conformational dynamics.

21 Dec 2024

New skin-like material could revolutionize infection testing

In the holiday movie The Grinch, makeup artists are reported to have spent several hours each day encasing Jim Carrey's face with prosthetics to create the iconic grumpy, green-furred creature.

20 Dec 2024

New research project aims to uncover molecular factors behind malaria’s deadliest strain

Nearly half the world's population lives in regions where malaria is endemic, with the parasite Plasmodium falciparum accounting for approximately 95% of malaria-related deaths globally.

20 Dec 2024

Solving a decades-long puzzle in leishmaniasis drug development

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts about 1 million people and kills about 30,000 people around the world every year.

20 Dec 2024

Assessing the impact of gozetotide in PSMA-positive prostate cancer

Gozetotide is a drug for diagnostic application in adults with prostate cancer. It is currently the only diagnostic agent that recognizes PSMA-positive prostate cancer and can therefore identify patients for whom PSMA-targeted therapy with (177Lu)lutetium vipivotide tetraxetan ("Lutetium-177" for short) is an option.

20 Dec 2024

Eyelashes as natural liquid deflectors for clear vision

Throughout human evolution, body and facial hair have notably diminished, yet eyelashes have remained a distinguishing feature.

20 Dec 2024

Scientists discover role of tumor stiffness in promoting cancer cell proliferation

In 2022 alone, over 20 million people were diagnosed with cancer, and nearly 10 million died from the disease, according to the World Health Organization.

20 Dec 2024

Study finds a subset of artificial heart patients can regenerate heart muscle

A research team co-led by a physician-scientist at the University of Arizona College of Medicine – Tucson's Sarver Heart Center found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

20 Dec 2024

Unexpected discovery opens doors for improved siRNA therapies

In everyday life, when things turn out the opposite of what you expect, it's usually cause for frustration. In science, it's often the starting point for discovery.

20 Dec 2024

Study reveals brain circuits and chemical messengers behind the regulation of meal initiation

When you are feeling hungry, the brain takes the necessary steps toward consuming a meal. Many of these steps are not well known, but a new study published in the journal Metabolism by researchers at Baylor College of Medicine and the University of Texas Health Science Center at Houston reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake.

20 Dec 2024

Groundbreaking study sets global handgrip strength benchmarks

Convenient, safe, and non-invasive, "handgrip strength" is a reliable predictor for age-related disease and disability.

20 Dec 2024

New insights into respiratory syncytial virus and prevention strategies

Respiratory syncytial virus (RSV) is a major cause of respiratory infections, particularly in infants, children under 5 years, and older adults. Its rapid spread makes RSV a serious public health concern. Currently, there are no effective medications for RSV, and current treatment focuses on providing supportive care and preventing its spread.

20 Dec 2024

Older women undergoing breast reconstruction may have increased risks for complications

For women undergoing breast reconstruction after mastectomy, older age is associated with small but significant increases in certain complications, reports a study in the January issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

20 Dec 2024

New prediction model improves early detection of infected pancreatic necrosis

A new prediction model for infected pancreatic necrosis (IPN) in patients with acute pancreatitis (AP) offers a groundbreaking approach to improving patient outcomes.

20 Dec 2024

Host heterogeneity increases pathogen virulence in metapopulations

Heterogeneity is ubiquitous in real-world host populations, yet most theories assume homogeneity. Using a metapopulation model, we examine how host heterogeneities, such as uneven movement patterns and local productivities, affect the evolution of pathogen virulence.

20 Dec 2024