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Protective gene variant slows Alzheimer’s by taming brain inflammation

A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine.

23 Jun 2025

New imaging breakthrough sheds light on brain communication pathways

For the first time, scientists using cryo-electron microscopy have discovered the structure and shape of key receptors connecting neurons in the brain's cerebellum, which is located behind the brainstem and plays a critical role in functions such as coordinating movement, balance and cognition.

23 Jun 2025

Common bacterium can turn everyday plastic waste into paracetamol

Paracetamol production could be revolutionized by the discovery that a common bacterium can turn everyday plastic waste into the painkiller, a study reveals.

23 Jun 2025

New DNA test predicts chemotherapy resistance in cancer patients

Cancer Research UK-funded scientists at the University of Cambridge, in collaboration with the Spanish National Cancer Research Centre (CNIO) and Cambridge-based startup Tailor Bio, have created a test which can successfully predict whether cancer will resist common forms of chemotherapy treatment.

23 Jun 2025

Inflammation drives early prostate cancer through cellular reprogramming

Prostate cancer is one of the most common cancers and the second leading cause of cancer-related death in men worldwide. However, the mechanisms controlling the early stages of prostate cancer formation are poorly understood.

23 Jun 2025

Melanoma’s excessive mitochondrial dependence becomes a therapeutic vulnerability

Researchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key processes in mitochondria, the components of cells that provide energy.

23 Jun 2025

Zebrafish study reveals hidden dangers in recycled plastic

A single pellet of recycled plastic can contain over 80 different chemicals. A new study with researchers from University of Gothenburg and Leipzig shows that recycled polyethylene plastic can leach chemicals into water causing impacts in the hormone systems and lipid metabolism of zebrafish larvae.

23 Jun 2025

Assessment of insulin resistance using TyG index flags rapid cognitive decline in Alzheimer's patients

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer's who are four times more likely to present rapid cognitive decline, according to new research presented at the European Academy of Neurology (EAN) Congress 2025.

22 Jun 2025

Scientists discover on/off gene switches that could revolutionize personalized medicine

Scientists identified 473 human genes that act as genetic “on/off switches,” shaping disease risk through tissue-specific or universal patterns regulated by DNA changes and hormones. These findings could pave the way for more precise diagnostics and personalized therapies across cancers, immune, skin, and metabolic diseases.

22 Jun 2025

Flies on dairy farms act as hidden carriers of superbugs and zoonotic threats

Researchers used deep metagenomic sequencing to trace zoonotic pathogens and antibiotic resistance genes from cow manure into the guts of muscid flies on a French dairy farm. Findings reveal that flies not only carry but may amplify dangerous microbes, underscoring public health risks.

22 Jun 2025

Researchers use electric fields to identify aged cells

Researchers from Tokyo Metropolitan University have created a new way of telling "aged" human cells apart from younger ones using electric fields.

21 Jun 2025

Hydration tips for active lifestyles in warmer weather

Exercising in the warmer weather is a welcome respite from winter, but summer workouts bring their own challenges, including dehydration.

21 Jun 2025

New intercellular network found to drive liver fibrosis progression

Liver fibrosis, a pathological condition in which the liver becomes stiff and scarred, commonly develops in the progression of chronic liver diseases such as chronic hepatitis and metabolic dysfunction-associated steatohepatitis (MASH).

21 Jun 2025

New brain study explains why some pain becomes chronic

A new study reveals that when we experience short-term (acute) pain, the brain has a built-in way to dial down pain signals - like pressing the brakes - to keep them from going into overdrive.

20 Jun 2025

Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML).

20 Jun 2025

Driving breakthroughs for the NF community at the 2025 NF Conference

A new era is unfolding for the NF community. With two FDA-approved treatments now on the market - including the first-ever therapy for adults with NF1 - and cutting-edge advances in AI, drug repositioning, and precision medicine, momentum is building like never before.

20 Jun 2025

Cord blood proteins help detect early sepsis in preterm infants

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues identified several proteins from the umbilical cord blood of preterm newborns that signal acute systemic inflammation as an immune response to infection, providing objective and noninvasive means to diagnose early onset sepsis.

20 Jun 2025

Discovery of key protein reveals why exercise strengthens muscles and bones

"Exercise is good for your health" is a well-known phrase, but few people can clearly explain how and why it benefits the human body."

20 Jun 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Multiple brain profiles underlie the same symptoms in depression

A novel study aimed at disentangling the neurological underpinnings of depression shows that multiple brain profiles may manifest as the same clinical symptoms, providing evidence to support the presence of both one-to-one and many-to-one heterogeneity in depression.

20 Jun 2025