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Adiponectin serves as energy-conserving signal to the brain

A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation, suggests a new study in the July issue of Cell Metabolism, a publication of Cell Press.

11 Jul 2007

Link between increased blood pressure and decreased pain perception

New research published in Psychophysiology finds a relationship between increased blood pressure and decreased pain perception in a variety of circumstances, including among individuals with heart disease.

11 Jul 2007

FDA says eating tomatoes does not decrease risk of cancer

A U.S. Food and Drug Administration (FDA) review has found only limited evidence for an association between eating tomatoes and a decreased risk of certain cancers, according to an article published online July 10 in the Journal of the National Cancer Institute.

11 Jul 2007

Incretin-based therapy offers alternative option for treating type 2 diabetes

A review of previous studies indicates that use of a class of medications known as “incretin-based therapy”, which act via certain pathways that affect glucose metabolism may provide modest effectiveness and favorable weight change outcomes for the treatment of type 2 diabetes and may represent an alternative to other hypoglycemic therapies.

11 Jul 2007

Catalyst Pharmaceutical Partners starts U.S. phase II trial of CPP-109 in patients with cocaine dependence

Catalyst Pharmaceutical Partners, Inc. a specialty pharmaceutical company that acquires or in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced that it has initiated its randomized, double-blind, placebo-controlled U.S. Phase II clinical trial of CPP-109 in patients with cocaine dependence.

11 Jul 2007

Hydroxychloroquine may reduce risk of diabetes in patients with rheumatoid arthritis

Preliminary research suggests that use of the anti-malarial drug hydroxychloroquine may help reduce the risk of the development of diabetes in patients with rheumatoid arthritis, according to a study in the July 11 issue of JAMA .

11 Jul 2007

Prophylactic antibiotics for children with UTI not associated with reduced risk of recurrence

The use of prophylactic antibiotics, which involves daily administration of antibiotics to children after an initial urinary tract infection, is not associated with reduced risk of recurrent urinary tract infections, but is associated with an increased risk of resistant infections, according to a study in the July 11 issue of JAMA.

11 Jul 2007

Development banks not fulfilling health pledges

Multilateral development banks are not fulfilling their commitments to support initiatives involving reproductive and sexual health in developing countries, according to a new study released by Gender Action, a Washington, D.C.-based organization that monitors the banks' policies on women and gender equality, Inter Press Service reports.

11 Jul 2007

Attitudes and experiences of community pharmacists towards paediatric off-label prescribing

Forty per cent of community pharmacists have dispensed an off-label drug to a child in the last month, according to research published in the July issue of the British Journal of Clinical Pharmacology.

11 Jul 2007

FDA says lycopene in tomatoes no use in fighting cancer

The U.S. Food and Drug Administration (FDA) in the United States has shot down in flames any claims that the lycopene found in tomatoes has cancer-preventing properties.

11 Jul 2007

Selenium supplements may do more harm than good

In a British trial examining the benefit of selenium supplements it has been found that in some cases the supplement can do more harm than good.

11 Jul 2007

Age-related macular degeneration associated with increased mortality risk

Individuals age 49 and older with cataract and those age 49 to 74 years with age-related macular degeneration appear to have higher mortality rates over an 11-year period than those without such visual impairments, according to a report in the July issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

10 Jul 2007

Percentage of inappropriate PSA screenings increases significantly with the age of male health care providers

Prostate-specific antigen (PSA) tests to screen for prostate cancer are frequently performed among patients for whom the PSA test is not shown to be beneficial, and clinicians with certain characteristics are more likely to order such inappropriate screening tests, according to a report in the July 9 issue of Archives of Internal Medicine.

10 Jul 2007

Some clinicians likely to order inappropriate prostate screenings

10 Jul 2007

Brain lesions may be sign of more widespread disease in the brain

Lesions commonly seen on MRI in the brains of older patients may be a sign of potentially more extensive injury to the brain tissue, according to a recent study conducted by researchers at the Duke University Medical Center, in Durham, NC.

10 Jul 2007

Selenium supplements appear to increase risk of developing type 2 diabetes

A new analysis of data from a large national study found that people who took a 200 microgram selenium supplement each day for almost eight years had an increased risk of developing type 2 diabetes than those who took a placebo or dummy pill.

10 Jul 2007

Cigarette smoking associated with reduced risk for developing Parkinson's disease

A pooled analysis of data from previous studies suggests that cigarette smoking appears to be associated with a reduced risk for developing Parkinson's disease, with long-term and current smokers at the lowest risk, according to a report in the July issue of Archives of Neurology.

10 Jul 2007

U.S. trial of new microbicide for HIV prevention to be tested in young women

Nearly half of all people infected with HIV/AIDS are now women, the majority of whom contracted the disease through sexual intercourse with male partners.

10 Jul 2007

People with early Parkinson's more likely to develop hallucinations, sleepiness and swelling

People with early Parkinson's disease report a higher than anticipated development or worsening of hallucinations, sleepiness, and swelling.

10 Jul 2007

National study to treat addiction to prescription pain medications

Researchers funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, launched the first large-scale national study evaluating a treatment for addiction to prescription opioid analgesics (i.e., painkillers) such as Vicodin and OxyContin.

10 Jul 2007

Drug Trial News

Adiponectin serves as energy-conserving signal to the brain

Link between increased blood pressure and decreased pain perception

FDA says eating tomatoes does not decrease risk of cancer

Incretin-based therapy offers alternative option for treating type 2 diabetes

Catalyst Pharmaceutical Partners starts U.S. phase II trial of CPP-109 in patients with cocaine dependence

Hydroxychloroquine may reduce risk of diabetes in patients with rheumatoid arthritis

Prophylactic antibiotics for children with UTI not associated with reduced risk of recurrence

Development banks not fulfilling health pledges

Attitudes and experiences of community pharmacists towards paediatric off-label prescribing

FDA says lycopene in tomatoes no use in fighting cancer

Selenium supplements may do more harm than good

Age-related macular degeneration associated with increased mortality risk

Percentage of inappropriate PSA screenings increases significantly with the age of male health care providers

Some clinicians likely to order inappropriate prostate screenings

Brain lesions may be sign of more widespread disease in the brain

Selenium supplements appear to increase risk of developing type 2 diabetes

Cigarette smoking associated with reduced risk for developing Parkinson's disease

U.S. trial of new microbicide for HIV prevention to be tested in young women

People with early Parkinson's more likely to develop hallucinations, sleepiness and swelling

National study to treat addiction to prescription pain medications

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