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Novartis announces FDA approval of its first and only CML therapy with TFR data in product label

Novartis announced today that the US Food and Drug Administration (FDA) approved the inclusion of Treatment-free Remission (TFR) data in the Tasigna® (nilotinib) US product label.

26 Dec 2017

T cell-inducing dengue vaccines could confer broader protection for kids born to vaccinated mothers

For a long time, a dengue vaccine was the holy grail in dengue research. Now that a dengue vaccine is finally on the market (Sanofi's Dengvaxia), other issues have arisen, such as what happens in the babies of vaccinated mothers.

22 Dec 2017

Study identifies biomarker targets to make existing drugs better at combating cancer

A new study published in Nature Communications and led by University of Kentucky Markey Cancer Center researcher Qing-Bai She identifies biomarker targets that may make existing drugs more effective in fighting certain cancers.

22 Dec 2017

FDA chief says he’s open to rethinking incentives on orphan drugs

The commissioner of the Food and Drug Administration questions whether the right financial incentives are in place for drugmakers who develop orphan drugs for rare diseases.

22 Dec 2017

Biosimilars, biologics and new legal challenges for RA treatments

Early last winter, Pfizer launched its new rheumatoid arthritis treatment, Inflectra, pricing it 15 percent below the $4,000-a-dose wholesale price of Remicade, the drug for which it is a close copy.

22 Dec 2017

FDA approves drug to increase blood pressure in adults with septic or distributive shock

The U.S. Food and Drug Administration today approved Giapreza (angiotensin II) injection for intravenous infusion to increase blood pressure in adults with septic or other distributive shock.

21 Dec 2017

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

The "mutational burden," or the number of mutations present in a tumor's DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows.

21 Dec 2017

Tumor growth traits can influence response to cancer drugs, study finds

Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi School of Engineering finds that tumor growth properties can influence response to cancer drugs.

21 Dec 2017

Drugs alone may not improve chances of successful quitting among smokers, study suggests

Pharmaceutical interventions are routinely prescribed to help people quit smoking. However, a new study by University of California San Diego School of Medicine researchers suggests that, despite promising results in clinical trials, smoking cessation drugs alone may not be improving the chances of successful quitting among smokers in general.

21 Dec 2017

FDA-approved drug to treat high blood pressure increases life span in worms

UT Southwestern Medical Center researchers find that an FDA-approved drug to treat high blood pressure seems to extend lifespan in worms via a cell signaling pathway that may mimic caloric restriction.

21 Dec 2017

New UGR study provides evidence for tramadol’s adverse effects on cycling performance

Tramadol is an opioid pain medication mainly used to treat moderate to severe pain, such as backache or postoperative pain. Although it has not yet been included in the list of banned substances by the World Anti-Doping Agency, the drug has recently generated significant media interest.

20 Dec 2017

High out-of-pocket costs act as barrier to potentially life-saving cancer treatments

Sticker shock may be leading many insured Americans with cancer to forego treatment with a wide range of oral cancer drugs, suggests a study published online this week in the Journal of Clinical Oncology.

20 Dec 2017

UTA researchers analyze challenges in pain management for the elderly

Researchers at The University of Texas at Arlington are focusing their attention on pain management in older adults, a segment of the population which presents a specific series of challenges to health providers.

20 Dec 2017

Clinical benefit of new cancer therapies may justify the expensive price

Researchers from the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, selected to estimate the cost-effectiveness of the newly approved CAR-T therapies, have found the clinical benefit may justify the expensive price.

20 Dec 2017

Antidepressant may also alleviate multiple sclerosis symptoms

The antidepressant clomipramine may also alleviate symptoms of multiple sclerosis (MS), specifically in its progressive form, i.e. when it occurs without relapses or remissions.

20 Dec 2017

Use of smoking cessation drug may put people at higher risk for cardiovascular events

Varenicline, one of the most commonly prescribed drugs for helping people quit smoking, may put them at higher risk for a cardiovascular event, according to new research published online in the American Journal of Respiratory and Critical Care Medicine.

20 Dec 2017

Study finds new way to explain hearing loss caused by cancer drug

Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear.

20 Dec 2017

FDA approves new gene therapy targeting rare form of inherited vision loss

The U.S. Food and Drug Administration today approved Luxturna (voretigene neparvovec-rzyl), a new gene therapy, to treat children and adult patients with an inherited form of vision loss that may result in blindness.

19 Dec 2017

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.

19 Dec 2017

UGR study paves way for development of better analgesics to treat joint pain

Researchers from the University of Granada have led a novel study in mice which shows that neurons mediating joint pain are different from those mediating cutaneous pain.

19 Dec 2017

Pharmaceutical News

Novartis announces FDA approval of its first and only CML therapy with TFR data in product label

T cell-inducing dengue vaccines could confer broader protection for kids born to vaccinated mothers

Study identifies biomarker targets to make existing drugs better at combating cancer

FDA chief says he’s open to rethinking incentives on orphan drugs

Biosimilars, biologics and new legal challenges for RA treatments

FDA approves drug to increase blood pressure in adults with septic or distributive shock

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

Tumor growth traits can influence response to cancer drugs, study finds

Drugs alone may not improve chances of successful quitting among smokers, study suggests

FDA-approved drug to treat high blood pressure increases life span in worms

New UGR study provides evidence for tramadol’s adverse effects on cycling performance

High out-of-pocket costs act as barrier to potentially life-saving cancer treatments

UTA researchers analyze challenges in pain management for the elderly

Clinical benefit of new cancer therapies may justify the expensive price

Antidepressant may also alleviate multiple sclerosis symptoms

Use of smoking cessation drug may put people at higher risk for cardiovascular events

Study finds new way to explain hearing loss caused by cancer drug

FDA approves new gene therapy targeting rare form of inherited vision loss

Study finds combination therapy as effective strategy to treat ovarian cancers

UGR study paves way for development of better analgesics to treat joint pain

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