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Patients with early-stage NSCLC and low SMARCA4 expression may benefit from platinum-based chemotherapy

The activity level of a particular gene in lung tumors might identify lung-cancer patients who will likely be helped by a particular chemotherapy regimen given to prevent recurrence after surgery.

11 Mar 2016

STING agonists developed to induce cellular death in B cell malignancies

In almost every mammalian cell, you will find the endoplasmic reticulum, a network of continuous membranes responsible for controlling metabolism as well as the folding, assembly and secretion of proteins.

11 Mar 2016

Popular kidney cancer drugs do not reduce incidence of recurrence

Two widely used targeted therapy drugs approved by the FDA for the treatment of metastatic kidney cancer—sorafenib and sunitinib—are no more effective than a placebo in preventing return of the disease to increase life spans of patients suffering from advanced kidney cancer after surgery, according to a new multi-institutional study in the Lancet led by a researcher at the Abramson Cancer Center (ACC) of the University of Pennsylvania.

10 Mar 2016

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.

10 Mar 2016

Meldonium use widespread among elite athletes

The use of meldonium--the substance taken by tennis star Maria Sharapova--is widespread among elite athletes, reveals research published online in the British Journal of Sports Medicine.

10 Mar 2016

Overprescribing of opioids leads to serious public health problems

Overprescribing of opioids and opioid addiction are serious and growing public health problems in the U.S., and are the focus of a new report by an expert panel, entitled The American Opioid Epidemic: Population Health Implications and Potential Solutions," from the National Stakeholder Panel, Jefferson College of Population Health, which is published in a special supplement to Population Health Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The supplement is available open access on the Population Health Managementwebsite

10 Mar 2016

Dihydroartemisinin-piperaquine effective in treating malaria in pregnant women

Pregnant women can be protected from malaria, a major cause of prematurity, low birth weight and death in infants in Africa, with dihydroartemisinin-piperaquine , an artemisinin combination therapy that is already widely used to treat malaria in adults, according to a study by researchers at UC San Francisco and in Uganda.

10 Mar 2016

New vaccine delays effects of nicotine within first 10 minutes after injection

Many people who smoke want to quit, but the urge to light up is often irresistible. An effective vaccine to help people kick the habit once and for all has been elusive. But now, scientists report in ACS' Journal of Medicinal Chemistry a new vaccine design that could help achieve this goal.

10 Mar 2016

Research could pave way for new generation of anti-cancer drugs

New research has identified a first step in the design of a new generation of anti-cancer drugs that include an agent to inhibit resistance to their effectiveness.

9 Mar 2016

New software takes ensemble approach to determine presence of chemical structure in drug molecule

A computer program that can predict whether or not a given pharmaceutical will have worrying side effects has been developed by researchers in the USA. Md Jamiul Jahid and Jianhua Ruan of the Department of Computer Science, at the University of Texas at San Antonio, have developed the "in silico" testing system for drugs in the early stage of drug development.

9 Mar 2016

Novel nanoparticle technology can decipher protein structures and help access drug targets

Researchers at Karolinska Institutet, Sweden, have developed a nanoparticle technology that can be used to stabilise membrane proteins so that their structure can be studied in a lipid environment. The method, described in Nature Methods, makes it possible to access drug targets that previously could not be investigated and therefore potentially allows for the development of novel drugs, therapeutic antibodies and vaccines.

9 Mar 2016

Use of OTC medication not always a smart decision for yeast infection

Itching, burning, redness—a yeast infection can be a total pain. While they aren't life-threatening, yeast infections are irritating—both physically and mentally. So, when undesirable symptoms appear 'down there,' should you consult your physician or self diagnose and treat with over-the-counter medications?

9 Mar 2016

Added benefit of multiple sclerosis drug fingolimod not proven, says IQWiG

Since its approval in 2011, the multiple sclerosis drug fingolimod (Gilenya) has already undergone three early benefit assessments, all of which were mainly based on the approval study TRANSFORMS. After a new modification of the therapeutic indication by the regulatory authorities, the Federal Joint Committee again commissioned the German Institute for Quality and Efficiency in Health Care to examine the added benefit of the drug in accordance with the Act on the Reform of the Market for Medicinal Products.

9 Mar 2016

Study: 40% of U.S. infants from low-income families do not receive rotavirus vaccination

Rotavirus (RV) infection is the leading cause of diarrheal disease in young children worldwide, causing more than half a million deaths of children aged <5 years annually, according to the World Health Organization. There are two safe and effective RV vaccines, pentavalent Rotateq (Merck) and monovalent Rotarix (GSK), yet global coverage remains below 20% of children.

9 Mar 2016

Therapy change significantly improves treatment outcomes for renal cell carcinoma patients

A research team of the Comprehensive Cancer Center of MedUni Vienna and AKH Vienna was able to demonstrate that a therapy change in the area of metastasising renal cell carcinoma significantly increases the life average expectancy and clearly improves the compatibility of the therapy.

9 Mar 2016

Antidepressants may play role in dental implant failure

Antidepressants, commonly used to treat anxiety, pain and other disorders, may play a role in dental implant failure, according to a new pilot study by University at Buffalo researchers.

8 Mar 2016

New possibilities in malaria drug development

Bringing three powerful chemical groups together offers new possibilities in drug development.A new chemical route for potential antimalarial compounds has been pioneered by chemists at KAUST. It offers hope for improved treatment of malaria, a disease that kills more than a million people each year

8 Mar 2016

Drug-incorporated nanoparticle platforms allow for selective targeting of cancer cells

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It is a leading cause of death and the burden is expected to grow worldwide due to the growth and aging of the population, mainly in less developed countries, in which about 82% of the world's population resides. By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Current cancer therapy approaches are based in surgery, radiotherapy and chemotherapy, being the chemotherapy the one that shows the greater efficiency for cancer treatment, mainly in more advanced stages. A major problem with this conventional chemotherapy is its toxicity and it also destroys healthy tissues resulting in systemic toxicity besides beneficial characteristics of killing cancer cells. Anticancer drugs also destroy healthy tissues resulting in systemic toxicity.

8 Mar 2016

SC Johnson delivers over 60,000 units of OFF! insect repellent to help protect families from Zika virus

Today, as part of its commitment to provide at least $15 million to help protect families from the Zika virus, SC Johnson announced a donation of more than 60,000 cans and bottles of OFF! personal insect repellent to the CDC Foundation, in partnership with the U.S. Centers for Disease Control and Prevention.

8 Mar 2016

New research reveals European women's attitudes towards sexual behaviours, emergency contraceptive pill

New research released on International Women’s Day, reveals more than three in four European women (77%) are aware of the morning after pill as an option for managing the risk of an unplanned pregnancy after unprotected sex or contraceptive failure.

8 Mar 2016

Pharmaceutical News

Patients with early-stage NSCLC and low SMARCA4 expression may benefit from platinum-based chemotherapy

STING agonists developed to induce cellular death in B cell malignancies

Popular kidney cancer drugs do not reduce incidence of recurrence

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Meldonium use widespread among elite athletes

Overprescribing of opioids leads to serious public health problems

Dihydroartemisinin-piperaquine effective in treating malaria in pregnant women

New vaccine delays effects of nicotine within first 10 minutes after injection

Research could pave way for new generation of anti-cancer drugs

New software takes ensemble approach to determine presence of chemical structure in drug molecule

Novel nanoparticle technology can decipher protein structures and help access drug targets

Use of OTC medication not always a smart decision for yeast infection

Added benefit of multiple sclerosis drug fingolimod not proven, says IQWiG

Study: 40% of U.S. infants from low-income families do not receive rotavirus vaccination

Therapy change significantly improves treatment outcomes for renal cell carcinoma patients

Antidepressants may play role in dental implant failure

New possibilities in malaria drug development

Drug-incorporated nanoparticle platforms allow for selective targeting of cancer cells

SC Johnson delivers over 60,000 units of OFF! insect repellent to help protect families from Zika virus

New research reveals European women's attitudes towards sexual behaviours, emergency contraceptive pill

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